1/11/2024 0 Comments Abnormal pupil reaction to light![]() Compared to controls, the latency of pupil contraction was increased in both subgroups of patients with ( P=0.014) and without ( P<0.001) persisting neurological symptoms. Amongst patients with COVID-19, 16/30 (53%) had at least one persisting neurological symptom beyond 4 weeks after infection. There was no significant difference in the initial pupil diameter, amplitude and velocity of pupil contraction, and latency, duration and velocity of pupil dilation, but the latency of pupil contraction was increased ( P<0.001) and the duration of pupil contraction was reduced ( P=0.029) in post-COVID-19 patients compared to healthy controls. The mean time after the diagnosis of COVID-19 was 3.6 ± 1.6 months. Post-COVID-19 patients and control participants were matched for age ( P=0.179) and gender ( P=0.522). Patients with diabetes mellitus or any other systemic disease that might cause autonomic dysfunction were excluded. A questionnaire in accord with the long-COVID guideline developed by the National Institute for Health and Care Excellence (NICE) was used to identify persisting symptoms more than 4 weeks. Thirty patients recovered from COVID-19 and 25 healthy control participants were studied using an infrared dynamic pupillometry system (MonPack One Metrovision, France) to quantify pupillary responses to white light stimulation (light intensity 100 cd/m 2, on/off time 200/3300 ms) (Figure 1). In this cross-sectional study, we assessed pupillary light reflex responses using dynamic pupillometry in patients after COVID-19. ![]() Neurological manifestations involving the central, peripheral, and autonomic nervous system have been reported in the acute phase of coronavirus disease 2019 (COVID-19) and have been shown to persist in a proportion of patients after recovery.
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